determination of lethal dose of plant extract

  • Effect of Aqueous Whole Plant Extract of Selaginella ...

    Effect of Aqueous Whole Plant Extract of Selaginella myosurus on Lipid Profile of Wistar Rats Omeodu S. I., ... Lethal Dose (LD 50) Determination LD 50 determination was done using an "up-and-down" procedure described by[23]. ... (400mg/kg b.w extract): A single daily dose of

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    BMRI BioMed Research International 2314-6141 2314-6133 Hindawi 10.1155/2017/6923629 6923629 Research Article Investigation into Hypoglycemic, Antihyperlipidemic, and ...

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  • Stanley MwebiaItonga (BVM-University of Nairobi) A thesis ...

    Bioactivity of Tephrosia vogelii extract was tested using brine shrimp lethality test. Acute toxicity of the same plant extract was studied in inbred albino weaned rats by determination of Median Lethal Dose (LD50), symptoms of toxicity and complete histopathology. The median lethal dose was determined using the method described by

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  • ISSN 2230 PHYTOCHEMICAL AND TOXICITY STUDY OF .

    fixed oils. For acute toxicity, including median lethal dose (LD 50) of amla, its HAE was administered @ 250, 500 and 1000 mg/kg body ... for quality control of plant-drug. The acute and chronic ... Preparation of extract and determination of extractability: ...

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  • Effect of Ethanol Leaf Extract of Newboulda Laevis on ...

    The acute toxicity of the plant extract was evaluated using the method described by Lorke [11]. The mice were divided into 5 ... determination were collected at intervals of 2, 4, 8, 24 h and on the 14 th day following ... routes, respectively. The median lethal dose (LD 50) was 6g/kg for the intraperitoneal route, and indeterminate for the ...

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  • Anti-diabetic effects of the methanolic extract of the ...

    Plant medicine (phytomedicine) has been used in health care ... Determination of median lethal dose (LD50) Acute toxicity study (LD50) was determined using the ... Group 3: Low Dose Extract Group. Rats in this group were treated with 100mg/kg bw of the extract of the rind

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  • Studies on the Toxicity of Ageratum conyzoides

    The mean lethal dose of ethanolic extract of Ageratum conyzoides was evaluated. ... Determination of Lethal Dose Thirty overnight fasted rats were divided into 6 groups (5 rats each). ... Administration of 1000 mg kg-1 of the plant extract produced a significant increase in the weight of the rats from the first to the last week of the experiment.

    Antioxidant and anticancer effect of methanolic extract of ...

    Determination of median lethal dose (LD 50) The LD 50 value was determined following conventional methods (Litchfield and Wilcoxon 1949). The test compound was dissolved in distilled water and injected intraperitoneally to six groups of mice (each containing n = 5) at .

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  • Radioprotective Effect of Fruit Extract of Grewia asiatica ...

    Albino Mice Against Lethal Dose of ... At this dose level GAE was found to be effective against different levels of radiation doses. LD 50/30 ... 2000) and plant extract of spinach (Bhatia and Jain, 2004), amaranths (Yadav et al, 2004; Verma et al, 2002), and linseed (Bhatia et al, 2006), to Swiss

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  • ANTI-VENOM POTENTIALS OF FRIEDELIN ISOLATED FROM .

    Median lethal dose determination (LD 50) of extract of Albizia chevalieri The methods of Lorkes (1983) was used: a total of 13 mice in two phases: phase one (3 groups, n=3) and phase two (4 groups, n=1). Evaluation of Inhibitory/Prophylaxis Effect of Crude Extracts/Fractions of A. chevalieri on Lethal Dose of the Crude Venom.

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  • BIOLOGICAL AND CHEMICAL EVALUATION OF THE USE OF .

    Dose = (yield % of fraction) x dose of extract/100 Determination of the Median Lethal Dose (L.D 50) of the Extract Adult male albino rats with average weight of (100-120) were used for the determination of median lethal dose (L.D 50) of the crude extract was a single oral dose through a stomach tube. The lethal dose fifty (L.D 50

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  • Effects of aqueous leaves extract of Ocimum gratissimum on ...

    The aqueous extract at the dose of 500 mg/kg significantly lowered blood glucose level (P<0.05) of the diabetic rats by 81.3% after 24 h of extract administration. ... The lethal doses (LD 50) of the plant extract was determined by method of Lorke (1983) using 13 rats. In the first phase, rats were ... Determination of the blood levels was done ...

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  • Aphrodisiac potentials of the ethanol extract of Aloe ...

    The acute toxicological evaluation of the plant were based on any onset behavioural changes and mortality respectively. ... Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats. Joseph ... It can therefore be inferred that the lethal dose (LD 50) of the extract is greater than 400 mg/kg since up to ...

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  • ISSN (E): 2320-3862 Preclinical screening of Antiulcer ...

    The lethal median dose (LD50) determination was done in rats by OECD guidelines 423 [16]. A single dose of the extracts (5 ... effects have been studied by administering the plant extract 30 min before each dose of phenylbutazone. After the dose ... The LD50 determination .

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  • Can you Overdose on Valerian Root? Possible Negative Effects

    Are there side effects from taking too much Valerian extract pills or tea? Recommended safe dosages to use. Nootropics. ... the herbaceous plant presents a bold display of bright while and pale pink flowers. ... Stahl E, Schild W. [Thin-layer chromatography for determination of pharmacopeia drugs. Valerian root, valerian .

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  • Determination of lethal concentration (LC50) values of ...

    Determination of lethal concentration (LC50) values of Cinnamomum zeylanicum hydrosol on carp fish ... -products or the byproducts of has been accompanied by stressful hydro- and steam distillation of plant conditions and problems related to fish material. ... herbal diet for producing quality Safety Dose Determination of larvae in Penaeus ...

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  • Asian Journal of Pharmaceutical and Clinical Research

    Neutralization of the lethal venom effect of Mesobuthus tamulus by plant extract at the dose of 1gm/kg and 2gm/kg by Alam and Gome''s method (in vitro) was also seen. Results: The LD 99 of Mesobuthus tamulus venom from this study was determined to be 25.12 µg/gm and LD 50 was 15.85 µg/gm.

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  • Acute and Subchronic Toxicity Study of Euphorbia hirta L ...

    To receive news and publication updates for BioMed Research International, enter your email address in the box below. ... The dried residue of plant extract was resuspended in DMSO (Sigma, USA) for further biological assay. ... and B. A. Burgess, "Estimation of acute oral toxicity in rats by determination of the approximate lethal dose rather ...

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  • Internet Scientific Publications

    The extract also caused a dose dependent significant increase in serum ALP, ALT and AST and a significant decrease in serum albumin. Significant increases in these liver enzymes may signify that there was a leakage of these enzymes from the liver due to liver damage (Nyblom et al ., 2004).

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  • Determination of LD50 and ED50 by dose response ...

    Plant material The seeds of ... 25, 50, 75, 100, 200, 300 mg/kg) of crude extract Analgesic Determination of LD 50 and ED 50 by dose response relationship and assessment of toxicological and non ... 100, 50, 25, 10, 1, 0.025 and 0.0125 mg/kg. The starting of lethal effect was recorded at the dose of 300 mg/kg and the calculated LD 50 value was ...

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  • Evaluation of anti-ulcer activity of the leaf extract of ...

    The oral median lethal dose (LD50) is estimated to be higher than 2000 mg/kg for the crude hydroalcoholic extract, and secondary metabolites such as flavonoids, tannins, and saponins were present. ... This model showed that the highest dose of the plant extract ... Naikwade NS. Evaluation of anti-ulcer activity of methanolic extract of Abutilon ...

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  • Evaluation of Acute and Subacute Toxicity of Fruit ...

    Determination of oral median lethal dose (LD 50) The oral median lethal dose (LD 50) of C. colocynthis and its range was determined according to the graphic method of Litchfield and Wilcoxon12. The fruit extract of C. colocynthis to be tested is dissolved in 600µl of ethanol, diluted by normal saline solution

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  • Laboratory determination of efficacy of indigenous plant ...

    Laboratory determination of efficacy of indigenous plant extracts for parasites control ... 2,000 ppm was prepared with 100 ml PBS solution and 1.0 ml of the desired plant extract concentration. ... Reddy PJ, Krishna D, Murthy US, Jamil K (1992) A microcomputer FORTRAN program for rapid determination of lethal concentration of biocides in ...

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  • lethal dose of plants

    Rotenone is a rotenoid plant extract obtained from such Humans are believed to be fairlysusceptible to the compound with an oral lethal dose estimated from. ... Guajillo is a nearly thornless The lethal dose of plant material for sheep and goats hasnot been determined. The toxic dosage is 15 times the animal''s weight ... determination of lethal ...

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  • Determination of Nutrient, Antinutrient Compositions and ...

    Determination of Nutrient, Antinutrient Compositions and Median Lethal Dose of Leaves of Microdesmis puberula ... crude protein, crude fibre, crude lipids, carbohydrate, phytic acid and hydrocyanide in the leaf extract of Microdesmis puberula. Levels of calcium, magnesium, iron, potassium and zinc were also evaluated in addition to the ...

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  • The Effect of Methanolic Leaf Extract of Adansoniadigitata ...

    Determination of Median Lethal Dose (LD50): Statistical Analysis: All data were expressed as Mean ± The median lethal dose forAdansonia digitataSEM and statistically analysed using One-way Analysis methanolic leaves extract was conducted using the of Variance .

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  • Determination of LD50 and ED50 by dose response ...

    EBSCOhost serves thousands of libraries with premium essays, articles and other content including Determination of LD50 and ED50 by dose response relationship and assessment of toxicological and non toxicological behaviour of Ipomoea hederacea. Get access to over 12 million other articles!

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  • The activity of alcoholic extract of Garlic on the growth ...

    determine the median lethal dose ( LD 50) of the extract in lab. mice. The Garlic was extracted ... Many plant-derived substances touted to improve health are sold around the world, Garlic (Allium sativum ) is believed ... 3- Determination of median lethal dose ( LD 50) of extract in lab. mice . ...

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  • Determination of Phytochemical Constituents of the Aqueous ...

    Determination of Phytochemical Constituents of the Aqueous Extracts of the Leaves, Stem ... A medicinal plant is any plant used for the ... Lethal dose 50 (LD. 50): Lethal dose 50 test involves the administration of aqueous extracts of a substance to a

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  • Hypoglycemic Activity of Artemisia herba-alba (Asso.) used ...

    Determination of the median lethal dose (L.D 50) of the crude extract Adult male albino rats with average weight of (100-120) were used for the determination of median lethal dose (L.D 50) of the crude extract was a single oral dose through a stomach tube. The lethal dose (L.D 50) of the 70% ethyl alcohol extract of

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  • MEDIAN LETHAL DOSE (LD50) EVALUATION OF SOME .

    Acute Toxicity Study (Median Lethal Dose (LD50) Determination): This was conducted in two phases using the method described by Lorke (1983). In the initial phase, mice were divided into 3 groups of three mice each and treated at doses of 10, 100 and 1000 mg/kg, respectively of each extract.

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  • STUDY THE PATHOLOGICAL EFFECTS OF CRUDE EXTRACT OF ...

    2- Median lethal dose Graduated doses of Portulaca oleracea ethanolic extract were dissolved in 10 ml distill water and administered S/C as 0.1 ml for each 10 gm of animal body weight. The range was of S/C single doses used in the determination of LD50 of the extract was (5000- 9500) mg /kg B.W.

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